The goal of this study was to look at the redox status of normal and abnormal crypts generated in azoxymethane-induced colon cancer in Fischer rats.
Methods: A total of 16 five-week-old male Fisher 344 rats (Rattus norvegicus) were housed individually in plastic cages with wood-chip bedding. The animals were acclimatised for one week and fed an ad libitum diet from the American Institute of Nutrition (AIN-93G). Their serum was tested for protein oxidation, DNA damage, lipid peroxidation and antioxidants, glutathione (GSH), and antioxidative enzymes.
The levels of protein oxidation and lipid peroxidation in the study group were substantially greater than in the control group (P0.01). The study group’s mean serum level of MDA and conjugated diene, on the other hand, was lower than the control group’s (P0.01). Antioxidative enzyme activity was considerably lower in the study group compared to the control group (P0.01). Conclusion: Because colorectal cancer is linked to oxidative stress, assessing oxidative stress and antioxidant intake could be a useful tool in the treatment and prevention of the disease.
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