The use of titanium dioxide and nanoparticles in ordinary products and our daily lives is extremely frequent. It is used as a culinary ingredient, as well as in dairy products, tooth paste, and a variety of commercial items such as paints, tiles, adhesives, and so on. For a time, its use was assumed to be safe, but new study indicates that it has a number of negative effects on human health. In this regard, the current study tried to investigate the ecotoxic effects of titanium dioxide nanoparticles on animal physiology using Rattus norvegicus liver tissue (Albino wister rats). Experimental mice were exposed to titanium dioxide nanoparticles in three different ways: acute oral toxicity (96 hours), short term oral toxicity (28 days), and sub chronic oral toxicity (98 days) (TiO2). According to IARC 2006, the LD50 (lethal dose 50) was determined, and 100 nm sized particles of TiO2 were dissolved in distilled water and administered as a single oral dose via canula. Because the liver is a detoxifying organ, its enzymes, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and bilirubin, are suggestive of excellent liver functionality and were assessed in all three terms of exposure. The results show that there are significantly greater levels of all important liver enzymes, implying that TiO2 has a harmful effect on the liver. This study clearly demonstrates TiO2as a toxicant affecting liver health and thus its indiscriminate use in several common items, which may be discouraged or used with caution, if not completely discontinued.

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