CADMIUM TOXICITY STUDIES AND THE EFFECT OF SEVERAL BIO FEEDS IN Labeo rohita (HAMILTON 1822) |  UTTAR PRADESH JOURNAL OF ZOOLOGY

The purpose of this study was to compare and contrast the proximate analysis, AST, ALT, LDH, and SDH levels in Labeo rohita gill, muscle, liver, and kidney. This is due to the great nutritional value of this fish as a source of protein in developing countries. The proximate analysis of L. rohita gathered from various locations in Melarungunam, Cudalore district, Tamil Nadu discovered that hatchery L. rohita had the highest protein (19.97%) and ash (1.76%) contents, while fat (0.84%), carbohydrate (5.39%), and dry matter (24.11%) contents. Labio rohita is a genus of plants. The fish morphology had the highest moisture content (81.42 percent ). During the enzymatic examination, the highest levels of peroxidase and – amylase activity were detected. The liver contained the most Cd metals, followed by the kidney, muscle, and gills in that order. When compared to other fish, fish treated with rice bran and tapioca powder grew the fastest.

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ACUTE TOXICITY STUDIES OF CADMIUM ON CRAB Sesarma quadratum (Decapoda) |  UTTAR PRADESH JOURNAL OF ZOOLOGY

An estuary is a brackish water feature that is partially contained along the coast, with one or more rivers or streams flowing into it and a free access to the open sea. Estuaries are an example of an ecotone, which is a transition zone between river and maritime habitats. Because many crustacean species live in estuaries, numerous research have been conducted to investigate the bioaccumulation and impact of various toxicants in these creatures. Heavy metals can build up in aquatic organisms’ tissues and induce a variety of harmful consequences on all organisms due to biomagnification. The goal of this study was to look at the acute toxicity of cadmium on crabs (Sesarma quadratum). Crab samples were subjected to varying amounts of cadmium (5, 10, 15, 20, and 25g/L) for 96 hours, and cumulative death was calculated in 24-hour intervals. SPSS 20 was used to analyse the data and provide a number of cumulative and fatal mortality rates.

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HISTOPATHOLOGICAL STUDY OF ORAL MAGNESIUM (MG) ADMINISTRATION AGAINST CHRONIC CADMIUM (CD) TOXICITY IN WISTAR RATS ON (LIVER, KIDNEY, SPLEEN AND BRAIN) | UTTAR PRADESH JOURNAL OF ZOOLOGY

In Wistar rats, cadmium toxicity caused damage and histopathological changes in the liver, kidneys, spleen and brain. The goal of this research was to investigate the possible protective effects of magnesium on tissue and organ histo-architectural integrity.

Forty male Wistar rats were randomly divided over 3 months into 4 groups: control group water, Cd group water and oral 15 mg/Kg CdCl2 dose, (Cd+Mg) group water and oral 15 mg/kg CdCl2+ 10 mg/kg MgCl2 dose, and Mg group water and oral 10 mg/kg MgCl2 dose, respectively. In order to demonstrate the beneficial effect of magnesium treatment against chronic cadmium toxicity, a histopathological analysis was performed.

Cadmium administration for 3 months resulted in apparent histologic defects, liver, kidney, spleen and brain damage and alterations. In contrast to the Cadmium Group, magnesium supplementation showed substantial histological improvements and markedly reduced tissue damage.

The findings of this study indicate that the oral administration of magnesium in rats exposed to cadmium chronic toxicity improved the histopathological changes observed in the liver, kidney, spleen, and brain without any detectable histoarchitectural modification in the organs of rats supplemented with magnesium.

Please see the link :- https://mbimph.com/index.php/UPJOZ/article/view/1614

HISTOPATHOLOGICAL STUDY OF ORAL MAGNESIUM (MG) ADMINISTRATION AGAINST CHRONIC CADMIUM (CD) TOXICITY IN WISTAR RATS ON (LIVER, KIDNEY, SPLEEN AND BRAIN) | UTTAR PRADESH JOURNAL OF ZOOLOGY

Toxicity by cadmium induced damages and histopathological changes in liver, kidneys, spleen and brain of Wistar rats. This research aimed at investigating the potential protective effects of magnesium on the histoarchitectural integrity of tissues and organs.

Forty male Wistar rats were randomly divided into 4 groups during 3 months: Control group received water, Cd group water and oral administration at dose 15 mg/Kg of CdCl2, (Cd+Mg) group water and oral administration at doses (15 mg / kg of CdCl2+ 10 mg/kg of MgCl2) and Mg group water and oral administration (10 mg/kg of MgCl2).

A histopahtological study was carried to show the beneficial effect of magnesium treatment against chronic cadmium toxicity.

Administration of cadmium for 3 months led to apparent histological abnormalities, damages and alterations to liver, kidney, spleen and brain. A supplementation of magnesium showed significant histological improvements and markedly reduced tissue damage when compared with Cadmium Group.

Results of this study demonstrate that the oral administration of magnesium in rats exposure to cadmium chronic toxicity ameliorated the histopathological changes observed in the liver, kidney, spleen and brain with no observable alteration in the histoarchitecture in the organs of the magnesium-supplemented rats.

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PROTECTIVE EFFECTS OF CURCUMIN AGAINST CADMIUM CHLORIDE INDUCED THYROTOXICITY IN ALBINO RATS

The present study aimed to investigate the time-related evaluation of the cytotoxic effects of cadmium chloride (CdCl2) and its prevention by Curcumin (Cur) in the thyroid gland of rats at two intervals. In this experiment, male Wistar albino rats were divided randomly into five groups (n=5), the first group (G1) kept as control. The second group (G2) was administrated a single dose of 50 mg/kg bw CdCl2 orally on the first day and left for 15 days. The third group (G3) was administered Cur at a dose of 150 mg/kg bw daily for 15 days. Group four rats (G4) were given a single oral dose of 50 mg/kg bw of CdCl2 on day one and 150 mg/kg bw of Cur daily for the next 15 days. Group 5 rats (G5) were given 150 mg/kg bw of Cur daily for 15 days and 50 mg/kg bw of CdCl2 on the last day. A similar experiment was performed for 30 days as well. After the treatment period, blood and thyroid tissue from each rat were processed for hormonal and biochemical analysis. In Cd-exposed rats, serum hormones (T3, T4 and TSH) showed significant deviation from normal, increased MDA content and lower activities of antioxidant enzymes (SOD and CAT) were evaluated as compared to control at both the intervals. In Cur supplemented rats, a significant improvement was observed at both the intervals of the experiment in comparison to Cd treated groups. Thus, Cur has the potential to combat Cd-induced oxidative stress and its effect becomes progressive with time.

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PROTECTIVE EFFECTS OF CURCUMIN AGAINST CADMIUM CHLORIDE INDUCED THYROTOXICITY IN ALBINO RATS

The present study aimed to investigate the time-related evaluation of the cytotoxic effects of cadmium chloride (CdCl2) and its prevention by Curcumin (Cur) in the thyroid gland of rats at two intervals. In this experiment, male Wistar albino rats were divided randomly into five groups (n=5), the first group (G1) kept as control. The second group (G2) was administrated a single dose of 50 mg/kg bw CdCl2 orally on the first day and left for 15 days. The third group (G3) was administered Cur at a dose of 150 mg/kg bw daily for 15 days. Group four rats (G4) were given a single oral dose of 50 mg/kg bw of CdCl2 on day one and 150 mg/kg bw of Cur daily for the next 15 days. Group 5 rats (G5) were given 150 mg/kg bw of Cur daily for 15 days and 50 mg/kg bw of CdCl2 on the last day. A similar experiment was performed for 30 days as well. After the treatment period, blood and thyroid tissue from each rat were processed for hormonal and biochemical analysis. In Cd-exposed rats, serum hormones (T3, T4 and TSH) showed significant deviation from normal, increased MDA content and lower activities of antioxidant enzymes (SOD and CAT) were evaluated as compared to control at both the intervals. In Cur supplemented rats, a significant improvement was observed at both the intervals of the experiment in comparison to Cd treated groups. Thus, Cur has the potential to combat Cd-induced oxidative stress and its effect becomes progressive with time.

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