EVALUATION OF OXIDATIVE STRESS IN AZOXYMETHANE-INDUCED COLON CANCEROUS FISCHER RATS |  UTTAR PRADESH JOURNAL OF ZOOLOGY

The goal of this study was to look at the redox status of normal and abnormal crypts generated in azoxymethane-induced colon cancer in Fischer rats.

Methods: A total of 16 five-week-old male Fisher 344 rats (Rattus norvegicus) were housed individually in plastic cages with wood-chip bedding. The animals were acclimatised for one week and fed an ad libitum diet from the American Institute of Nutrition (AIN-93G). Their serum was tested for protein oxidation, DNA damage, lipid peroxidation and antioxidants, glutathione (GSH), and antioxidative enzymes.

The levels of protein oxidation and lipid peroxidation in the study group were substantially greater than in the control group (P0.01). The study group’s mean serum level of MDA and conjugated diene, on the other hand, was lower than the control group’s (P0.01). Antioxidative enzyme activity was considerably lower in the study group compared to the control group (P0.01). Conclusion: Because colorectal cancer is linked to oxidative stress, assessing oxidative stress and antioxidant intake could be a useful tool in the treatment and prevention of the disease.

Please see the link :- http://mbimph.com/index.php/UPJOZ/article/view/2581

EXOGENOUS MELATONIN REVIVES THE LETROZOLE INDUCED TOXIC VARIATIONS IN BIOCHEMICAL PARAMETERS IN POLYCYSTIC OVARY SYNDROME IN RATS | UTTAR PRADESH JOURNAL OF ZOOLOGY


Patients in one group were given nebulized fentanyl (4 mcg/kg) and IV saline, whereas participants in the other group were given intravenous fentanyl (1 mcg/kg) and nebulized saline, and postoperative analgesic efficacy was measured using a visual analogue scale (VAS) score. Both the group and the group had a mean baseline heart rate of 917.76 and 945.48, respectively. The change in heart rate recorded in both groups over time was nearly identical, and the difference detected was statistically insignificant. Both groups had statistically significant variations in systolic and diastolic blood pressure, although the difference was not clinically significant.


Please see the link :- http://mbimph.com/index.php/UPJOZ/article/view/1797

ENDOGENOUS ANTIOXIDANT COMPLEX AND SUPEROXIDE DISMUTASE PERFORMED IN SOME NON-AIRBREATHING FISHES | UTTAR PRADESH JOURNAL OF ZOOLOGY

The toxic effect could be evaluated through the assay of antioxidant enzymes. Such enzymes safeguard life forms against oxidative damage by toxic metals. Oxidative stress has been a significant feature of toxicology in recent times and also has gained growing recognition. Analysis has developed from the simple study of the symptoms of oxidative damage only at stage of the organism to the explanation of the fundamental processes at the biochemical and metabolic stages. There is the confirmation that oxidative stress often has an ecological significance, especially in the aquatic ecosystem, which is really the ultimate trap for several oxidative stress-producing contaminants. Based on the evidence presented with both mammalian and swimming pool environments, the detrimental and adaptive pathways of oxidative stress tend to be somewhat identical. The current study also points out is that fish can serve as significant bio – indicators and therefore can act as a viable substitute. In the present study a survey of levels of the antioxidant defence enzyme, superoxide dismutase were conducted in a varieties of water non Air breathing fishes collected from different sites using various metabolically active tissues (viz. liver, brain, kidney, gills, heart etc.) of the investigated fishes. The results showed that the highest Cu-Zn SOD (9.3 unites. mg-1 protein) was found in liver and lowest Cu-Zn SOD (0.1 units. mg-1 protein) was observed in the brain tissue of the fish Labeo rohita compared with other ones.

Please see the link :- https://mbimph.com/index.php/UPJOZ/article/view/1687

ENDOGENOUS ANTIOXIDANT COMPLEX AND SUPEROXIDE DISMUTASE PERFORMED IN SOME NON-AIRBREATHING FISHES | UTTAR PRADESH JOURNAL OF ZOOLOGY

The toxic effect could be evaluated through the assay of antioxidant enzymes. Such enzymes safeguard life forms against oxidative damage by toxic metals. Oxidative stress has been a significant feature of toxicology in recent times and also has gained growing recognition. Analysis has developed from the simple study of the symptoms of oxidative damage only at stage of the organism to the explanation of the fundamental processes at the biochemical and metabolic stages. There is the confirmation that oxidative stress often has an ecological significance, especially in the aquatic ecosystem, which is really the ultimate trap for several oxidative stress-producing contaminants. Based on the evidence presented with both mammalian and swimming pool environments, the detrimental and adaptive pathways of oxidative stress tend to be somewhat identical. The current study also points out is that fish can serve as significant bio – indicators and therefore can act as a viable substitute. In the present study a survey of levels of the antioxidant defence enzyme, superoxide dismutase were conducted in a varieties of water non Air breathing fishes collected from different sites using various metabolically active tissues (viz. liver, brain, kidney, gills, heart etc.) of the investigated fishes. The results showed that the highest Cu-Zn SOD (9.3 unites. mg-1 protein) was found in liver and lowest Cu-Zn SOD (0.1 units. mg-1 protein) was observed in the brain tissue of the fish Labeo rohita compared with other ones.

Please see the link :-  https://mbimph.com/index.php/UPJOZ/article/view/1687

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